I’m Susan’s clock. I pass the time while Susan is out most of the day traveling to follow-up doctors appointments. If she remains untreated, the unaddressed anemia that Susan is experiencing can increase the risk of dangerous consequences such as:

References: 1. Sharma VR. Paroxysmal nocturnal hemoglobinuria: pathogenesis, testing, and
diagnosis. Clin Adv Hematol Oncol. 2013;11(suppl 13)(9):2-8. 2. Gao C, Li L, Chen B, et al. Clinical
outcomes of transfusion-associated iron overload in patients with refractory chronic anemia. Patient Prefer Adherence. 2014;8:513-517. 3. Neme-Yunes Y, Guerrero-Sánchez E, Pérez-Zepeda MU, López-Karpovitch X. Iron overload: an overlooked complication in classic paroxysmal nocturnal hemoglobinuria. Rev Hematol Mex. 2016;17(4):233-238.

I’m Susan’s desk. I hardly ever get worked on these days. Due to the debilitating effects throughout Susan’s body that she experiences every day, Susan is unable to work full-time anymore. These effects can include:

Renal damage may not be clinically apparent but can occur at any point in time, increasing the risk of acute kidney injury, chronic renal dysfunction, and renal failure in patients with PNH.³

Hb=hemoglobin.

References: 1. Jang JH, Kim JS, Yoon SS, et al. Predictive factors of mortality in population of patients with paroxysmal nocturnal hemoglobinuria (PNH): results from a Korean PNH registry. J Korean Med Sci. 2016;31(2):214-221. 2. Peacock-Young B, Macrae FL, Newton DJ, Hill A, Ariëns RAS. The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source. Haematologica. 2018;103(1):9-17. 3. Sahin F, Ozkan MC, Mete NG, et al. Multidisciplinary clinical management of paroxysmal nocturnal hemoglobinuria. Am J Blood Res. 2015;5(1):1-9.